About re-evaluation
To ensure the business continuity during the COVID-19 outbreak, any data related to the safety re-evaluation of food additives (e.g. replies to DG SANTE calls for data related to the follow-up on the safety re-evaluation of food additives) should be submitted to the Commission by using the online platform CIRCABC. These measures will remain in place until further notice. No parallel or later submission of the same data in a physical medium (as well as paper copies) is required.
Please check the Guidance for online data submission on Food Improvement Agents via CIRCABC Sante-Cad-In Group for further practical information on how to use the CIRCABC platform for the online submissions.
Food additives permitted before 20 January 2009 must go through a new risk assessment by the European Food Safety Authority (EFSA).
Commission Regulation (EU) No 257/2010 set up a programme for the re-evaluation of approved food additives in accordance with Regulation (EC) No 1333/2008.
Regulation (EU) 2019/1381 on the transparency and sustainability of the EU risk assessment in the food chain amended Regulation (EC) No 178/2002 and Regulation 1331/2008 establishing a common authorisation procedure for food additives, food enzymes and food flavourings and is applicable as of 27 March 2021. Further information on the implementation of that Regulation can be found on DG SANTE’s website .
Commission Regulation (EU) No 257/2010 has been adjusted by Commission Implementing Regulation (EU) 2021/148 in order to provide for levels of transparency and confidentiality that are comparable to those applicable in the context of the procedure for updating the Union list of approved food additives, while taking into account of the specificities of the re-evaluation procedure.
Clarification on transitional provisions for E 422, E 475 and E 476 as laid down by Commission Regulation (EU) 2023/1329 and for E 471 as laid down by Commission Regulation (EU) 2023/1428
The European Commission adopted, on 29 June 2023, Regulation (EU) 2023/1329 amending the specification for glycerol (E 422), polyglycerol esters of fatty acids (E 475) and polyglycerol polyricinoleate (E 476). On 7 July 2023, the European Commission adopted Regulation (EU) 2023/1428 amending the specification for mono- and diglycerides of fatty acids (E 471).
Commission Regulation (EU) No 2023/1329 enters into force on 20 July 2023, i.e. on the twentieth day following that of its publication in the Official Journal of the European Union and Commission Regulation (EU) No 2023/1428 enters into force on 30 July 2023.
In order to mitigate the potential impact on food business operators, transitional measures were included in the Regulation. Please see the schematic representation of the transitional measures.
Questions & Answers on titanium dioxide
A selection of the most frequently asked questions through the re-evaluation process:
The European Commission has adopted, on 14 January 2022, Regulation (EU) 2022/63withdrawing the authorisation to use a food additive Titanium dioxide (TiO2 also known as E171) in food products.
This measure was endorsed unanimously by the Member States in the context of a Standing Committee on Plants, Animals, Food and Feed.
The Regulation entered into force on 7 February 2022, i.e. on the twentieth day following that of its publication in the Official Journal of the European Union.
E171 used to be added as a colour to a number of foods such as cakes and pastries, confectionary or food supplements.
In order to mitigate the potential impact on food business operators, transitional measures were included in the Regulation allowing to continue placing on the market food containing E 171 for a limited period of time, while food business operators were working on the reformulation of their products.
Therefore, the Regulation allowed, until 7 August 2022, to place on the market foods containing titanium dioxide, in accordance with the conditions given by the legislation applicable before 7 February 2022. Those foods may remain on the market until their date of minimum durability or ‘use by’ date.
Surveillance of the markets is under the competence and responsibility of Member States’ food safety authorities, which will make sure that food containing titanium dioxide is not placed on the EU market anymore.
Products produced and kept in storage for the purpose of sale (i.e. placed on the market*) as finished products (i.e. food which will be as such offered for sale to the final consumer) until 7 August 2022, can continue being sold until their shelf life expires, by any operator, as long as it is not transformed and thus not used for the manufacturing of compound products. Therefore, sales B2B are still possible as long as the product is finished and will not be further transformed along the supply chain.
* "Placing on the market" includes all sales and supplies, including one-off sales, one-off supplies free of charge, and holding food for the purpose of sale. It covers food products which have already been produced by food business operators or imported and are being held with a view to sale or supply free of charge. It does not include food products which are still under processing, or raw materials provided by suppliers.
The Commission prepared its proposal on the basis of a scientific opinion from EFSA, published on 6 May 2021, which concluded that E171 can no longer be considered as safe when used as food additive. This conclusion was reached using all available evidence along with all the uncertainties, in particular the fact that a genotoxicity concern could not be ruled out.
EFSA did not conclude that E171 is genotoxic, but it was not able to establish a maximum Acceptable Daily Intake (ADI) for this food additive, in particular due to possible concerns with respect to genotoxicity, and thus concluded that the safety of the product cannot be confirmed.
Genotoxicity is the ability for a substance or any other toxic agent to damage DNA, the genetic material of cells, which may in turn, as a possible consequence, lead to cancer.
This assessment also took into account new data that were not available when EFSA re-evaluated E 171 in 2016, and made use, for the first time, of the 2018 EFSA Guidance on nanotechnology.
Moreover, EFSA also searched for studies performed specifically with titanium dioxide nanoparticles.
This led to the identification of almost 10.000 different studies, which have been individually screened and, when relevant, taken into account in the safety assessment of E 171.
In line with the applicable legislation and on the basis of the European Medicines Agency (EMA) analysis on the use of titanium dioxide in medicines published 8 October 2021, Regulation (EU) 2022/63 foresees that titanium dioxide remains for the time being on the list of authorised additives to allow its use in medicinal products as a colour. One of the reasons for that decision is to avoid shortages of medicinal products containing the colourant as this could impact public health, animal health and welfare. The replacement of titanium dioxide will also require investigation and testing of suitable alternatives to ensure that quality, safety and efficacy of medicines is not affected negatively.
A review clause is in the Regulation according to which the Commission is to re-evaluate the situation within 3 years after the date of entering into force of the Regulation, on the basis of an updated assessment by the EMA.
This gives a clear sign that the pharmaceutical industry should make any possible efforts to accelerate the research and development of alternatives to replace titanium dioxide in both new and already authorised products, and to submit the necessary changes to the terms of the marketing authorisations concerned.
More information:
- Final feedback from European Medicine Agency (EMA) to the EU Commission request to evaluate the impact of the removal of Titanium dioxide from the list of authorised food additives on medicinal products
- Annex I - Use of titanium dioxide as excipient in human medicines - Industry feedback to QWP Experts / EMA questions
- Annex 2 - Use of titanium dioxide as excipient in veterinary medicines - Industry feedback to QWP Experts / EMA questions
Deadlines for re-evaluation:
| Most food colours | by the end of 2011 (closed) |
| Aspartame | by November 2013 (closed) - NB: this re-evaluation was advanced due to the publication of new scientific data |
| Remaining colours | by the end of 2015 (closed) |
| Preservatives, antioxidants, glutamates, silicon dioxide | by the end of 2015-2016 (closed) |
| Other sweeteners | by the end of 2020 (ongoing) |
| All other additives | by the end of 2018 (ongoing) |
State of play of the re-evaluation of safety of permitted food additives by EFSA as of 1 September 2024:
- 315 food additives approved before 20 January 2009 to be re-evaluated by EFSA
- 127 scientific opinions published by EFSA on the re-evaluation of the safety of food additives, covering 231 individual food additives
- 84 food additives still to be re-evaluated by EFSA
Summary table of permitted food additives and status of their re-evaluation by EFSA (status as of 1 September 2024).
Approach for the follow-up of EFSA’s scientific opinions on the re-evaluation of the safety of permitted food additives for which some concerns have been identified.
EFSA scientific opinion - Follow-ups
- Template for reporting data on the use of E 1404-1451 in accordance with Annex II, Part E to Regulation (EC) No 1333/2008
- Template for reporting data on the use of E 1420 and E 1451 in accordance with Annex III to Regulation (EC) No 1333/2008
- Published: 20 March 2024
- Deadline for step 1 (Registration of the contact details of business operators interested in submitting data): 17 May 2024
- Deadline for step 2 (Confirmation of data submission, deadlines and milestones): 20 September 2024
- Template for reporting data on the use of E 338–341, E 343, E 450–452 in accordance with Annex II, Part E to Regulation (EC) No 1333/2008
- Template for reporting data on the use of E 338–341, E 343, E 450–452 in accordance with Annex III to Regulation (EC) No 1333/2008
- Published: 05/07/2023
- Deadline: 05/03/2024
- Published: 26/10/2022
- Registration of the contact details of business operators interested in submitting data (step 1)
- Deadline: 7/12/2022
- List of interested business operators
- Confirmation of data submission, deadlines and milestones (step 2)
- Deadline: 26/04/2023
- Outcome of step 2 of the call for data and overview of data that will be submitted, deadlines and milestones
- Published: 07/12/2022
- Deadline: 18/01/2023 (Please note that this is the final deadline for submission of the technical data requested in the call)
Call for technical and toxicological data on citric acid esters of mono- and diglycerides of fatty acids (E 472c) for uses as a food additive in foods for all population groups including infants below 16 weeks of age
- Published: 1/12/2021
- Deadline for registering interest: 11/01/2022
- Deadline for submission of data: 31/08/2022
- New deadline for submission of data: 30/06/2023
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of citric acid esters of mono- and diglycerides of fatty acids (E 472c) as food additive, during its upcoming risk assessment of citric acid esters of mono- and diglycerides of fatty acids (E 472c) for uses in food for young infants. Therefore, specific data requirements for all uses of citric acid esters of mono- and diglycerides of fatty acids (E 472c) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this side. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted are not sufficient for EFSA to conclude the risk assessment, since there will be no successive call for additional data.
Call for technical data on sucrose esters of fatty acids (E 473) for uses as a food additive in foods for all population groups including infants below 16 weeks of age
- Published: 8/12/2021
- Deadline for registering interest: 18/1/2022
- Deadline for submission of data: 8/9/2022
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of sucrose esters of fatty acids (E 473) as food additive, during its upcoming risk assessment of sucrose esters of fatty acids (E 473) for uses in food for young infants. Therefore, specific data requirements for all uses of sucrose esters of fatty acids (E 473) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this side. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted are not sufficient for EFSA to conclude the risk assessment, since there will be no successive call for additional data.
Call for technical data on the permitted food additive metatartaric acid (E 353)
Published: 19/1/2021
Deadline: 19/7/2021 (Please note that this is the final deadline for submission of the technical data requested in the call)
New deadline for submission of data: 30/11/2022
Published: 19/1/2021
Deadline: 18/9/2021
New deadline: 18/8/2022 (Please note that this is the final deadline for submission of the technical data requested in the call)
Published: 19/1/2021
Deadline: 19/7/2021 (Please note that this is the final deadline for submission of the technical data requested in the call)
New deadline for submission of data: 30/09/2022
Call for technical data on the permitted food additive stearyl tartrate (E 483)
Published: 19/1/2021
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 2/3/2021
Confirmation of data submission, deadlines and milestones (step 2)
Deadline: 19/7/2021
Outcome of the call for data: No reply to the step 1 of the call for scientific and technical data on the permitted food additive stearyl tartrate (E 483) was received.
Call for technical data on the permitted food additive vegetable carbon (E 153)
Published: 15/12/2020
Deadline: 14/8/2021 (Please note that this is the final deadline for submission of the technical data requested in the call)
Call for technical data on the permitted food additive quillaia extract (E 999)
Published: 15/12/2020
Deadline: 14/7/2021 (Please note that this is the final deadline for submission of the technical data requested in the call)
New Deadline: 14/9/2021 (Please note that this is the final deadline for submission of the technical data requested in the call)
Call for technical and toxicological data on carrageenan (E 407) for uses as food additive in foods for all population groups including infants below 16 weeks of age
Published: 10/10/2018
Deadline for registering interest: 21/11/2018
Deadline for submission of data: 30/09/2020
New deadline for submission of data: 31/12/2022
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of carrageenan (E 407) as a food additive, during its upcoming risk assessment of carrageenan (E 407) for uses in food for young infants. Therefore, specific data requirements for all uses of carrageenan (E 407) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted are not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for technical and toxicological data on mono- and di-glycerides of fatty acids (E 471) for uses as a food additive in foods for all population groups including infants below 16 weeks of age
Published: 29/11/2018
New deadline for submission of data: 30/12/2020
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of mono- and di-glycerides of fatty acids (E 471) as a food additive, during its upcoming risk assessment of mono- and di-glycerides of fatty acids (E 471) for uses in food for young infants. Therefore, specific data requirements for all uses of mono- and di-glycerides of fatty acids (E 471) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted are not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for technical data on the permitted food additive polyglycerol esters of fatty acids (E 475)
Published: 23/11/2018
New Deadline: 30/12/2020 (Please note that this is the final deadline for submission of the technical data requested in the call)
Call for technical data on the permitted food additive polyglycerol polyricinoleate (E 476)
Published: 23/11/2018
New Deadline: 30/12/2020 (Please note that this is the final deadline for submission of the technical data requested in the call)
Call for scientific and technical data on xanthan gum (E 415) for uses as a food additive in foods for all population groups including infants below 16 weeks of age
Published: 18/7/2018
Deadline for registering interest: 26/9/2018
New deadline for submission of data: 30/06/2020
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of xanthan gum (E 415) as a food additive, during its upcoming risk assessment of xanthan gum (E 415) for uses in food for young infants. Therefore, specific data requirements for all uses of xanthan gum (E 415) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted is not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for scientific and technical data on locust bean gum (E 410) for uses as a food additive in foods for all population groups including infants below 16 weeks of age
Published: 18/7/2018
Deadline for registering interest: 26/9/2018
New deadline for submission of data: 31/10/2020
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of locust bean gum (E 410) as a food additive, during its upcoming risk assessment of locust bean gum (E 410) for uses in food for young infants. Therefore, specific data requirements for all uses of locust bean gum (E 410) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted is not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Published: 11/04/2019
Deadline: 13/01/2020 (Please note that this is the final deadline for submission of the technical data requested in the call)
Call for technical and toxicological data on sucrose esters of fatty acids (E 473) for uses as a food additive in foods for all population groups including infants below 16 weeks of age
Published: 29/11/2018
Deadline for submission of data: 31/12/2019
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of sucrose esters of fatty acids (E 473) as a food additive, during its upcoming risk assessment of sucrose esters of fatty acids (E 473) for uses in food for young infants. Therefore, specific data requirements for all uses of sucrose esters of fatty acids (E 473) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted are not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for technical and toxicological data on tocopherol-rich extract (E 306), α-tocopherol (E 307), γ-tocopherol (E 308) and δ- tocopherol (E 309) for uses as food additives in foods for all population groups including infants below 16 weeks of age
Published: 10/10/2018
Deadline for registering interest: 21/11/2018
Deadline for submission of data: 31/05/2020
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of tocopherol-rich extract (E 306), α-tocopherol (E 307), γ-tocopherol (E 308) and δ- tocopherol (E 309) as food additives, during its upcoming risk assessment of tocopherol-rich extract (E 306), α-tocopherol (E 307), γ-tocopherol (E 308) and δ- tocopherol (E 309) for uses in food for young infants. Therefore, specific data requirements for all uses of tocopherol-rich extract (E 306), α-tocopherol (E 307), γ-tocopherol (E 308) and δ- tocopherol (E 309) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted are not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for technical and toxicological data on silicon dioxide (E 551) for uses as food additive in foods for all population groups including infants below 16 weeks of age
Published: 10/10/2018
Deadline for registering interest: 21/11/2018
deadline for submission of data: 31/05/2020
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of silicon dioxide (E 551) as a food additive, during its upcoming risk assessment of silicon dioxide (E 551) for uses in food for young infants. Therefore, specific data requirements for all uses of silicon dioxide (E 551) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted are not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for scientific and technical data on sodium carboxymethylcellulose (E 466) for uses as a food additive in foods for all population groups including infants below 16 weeks of age.
Published: 18/7/2018
Deadline for registering interest: 26/9/2018
deadline for submission of data: 31/12/2019
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of sodium carboxymethylcellulose (E 466) as a food additive, during its upcoming risk assessment of sodium carboxymethylcellulose (E 466) for uses in food for young infants. Therefore, specific data requirements for all uses of sodium carboxymethylcellulose (E 466) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted is not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for scientific and technical data on pectin (E440i) and amidated pectin (E 440ii) for uses as food additives in foods for all population groups including infants below 16 weeks of age.
Published: 18/7/2018
Deadline for registering interest: 26/9/2018
deadline for submission of data: 31/12/2019
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of pectin (E440i) and amidated pectin (E 440ii) as food additives, during its upcoming risk assessment of pectin (E440i) and amidated pectin (E 440ii) for uses in food for young infants. Therefore, specific data requirements for all uses of pectin (E440i) and amidated pectin (E 440ii) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of these food additives will be revised based on EFSA’s current scientific opinion and these additives may be removed from the Union list of permitted additives. The same applies if the new data submitted is not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for scientific and technical data on guar gum (E 412) for uses as a food additive in foods for all population groups including infants below 16 weeks of age
Published: 18/7/2018
Deadline for registering interest: 26/9/2018
deadline for submission of data: 31/12/2019
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of guar gum (E 412) as a food additive, during its upcoming risk assessment of guar gum (E 412) for uses in food for young infants. Therefore, specific data requirements for all uses of guar gum (E 412) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted is not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for scientific and technical data on lecithins (E 322) for uses as a food additive in foods for all population groups including infants below 16 weeks of age
Published: 18/7/2018
Deadline for registering interest: 26/9/2018
deadline for submission of data: 31/12/2019
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of lecithins (E 322) as a food additive, during its upcoming risk assessment of lecithins (E 322) for uses in food for young infants. Therefore, specific data requirements for all uses of lecithins (E 322) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted is not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for technical data on the permitted food additive glycerol (E 422)
Published: 23/11/2018
Deadline: 30/6/2019 (Please note that this is the final deadline for submission of the technical data requested in the call)
Published: 23/11/2018
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 21/1/2019 (CLOSED)
Confirmation of data submission, deadlines and milestones (step 2)
Deadline: 20/5/2019 (CLOSED)
Call for technical and toxicological data on calcium carbonate (E 170) for uses as food additive in foods for all population groups including infants below 16 weeks of age
Published: 10/10/2018
Deadline for registering interest: 21/11/2018
New deadline for submission of data: 30/08/2019
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of calcium carbonate (E 170) as a food additive, during its upcoming risk assessment of calcium carbonate (E 170) for uses in food for young infants. Therefore, specific data requirements for all uses of calcium carbonate (E 170) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted are not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for scientific and technical data on starch sodium octenyl succinate (E 1450) for uses as a food additive in foods for all population groups including infants below 16 weeks of age.
Published: 18/7/2018
Deadline for registering interest: 26/9/2018
deadline for submission of data: 31/12/2018
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of starch sodium octenyl succinate (E 1450) as a food additive, during its upcoming risk assessment of starch sodium octenyl succinate (E 1450) for uses in food for young infants. Therefore, specific data requirements for all uses of starch sodium octenyl succinate (E 1450) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted is not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Published: 24/10/2018
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 6/12/2018 (CLOSED)
Confirmation of data submission, deadlines and milestones (step 2)
Deadline: 15/4/2019 (CLOSED)
List of data that will be submitted, deadlines and milestones
Published: 12/10/2018
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 30/11/2018 (CLOSED)
Confirmation of data submission, deadlines and milestones (step 2)
Deadline: 31/1/2019 (CLOSED)
Call for technical and toxicological data on ascorbyl palmitate (E 304(i)) for uses as food additive in foods for all population groups including infants below 16 weeks of age
Published: 10/10/2018
Deadline for registering interest: 21/11/2018 (CLOSED)
New deadline for submission of data: 31/07/2019
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of ascorbyl palmitate (E 304(i)) as a food additive, during its upcoming risk assessment of ascorbyl palmitate (E 304(i)) for uses in food for young infants. Therefore, specific data requirements for all uses of ascorbyl palmitate (E 304(i)) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted are not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for technical and toxicological data on acacia gum (E 414) for uses as food additive in foods for all population groups including infants below 16 weeks of age
Published: 10/10/2018
Deadline for registering interest: 21/11/2018 (CLOSED)
deadline for submission of data: 28/02/2019 (CLOSED)
This call for data is organised by the European Food Safety Authority (EFSA), since the European Commission requested EFSA to address the data gaps identified in the scientific opinion on the re-evaluation of acacia gum (E 414) as a food additive, during its upcoming risk assessment of acacia gum (E 414) for uses in food for young infants. Therefore, specific data requirements for all uses of acacia gum (E 414) are included in this call for data. The call procedures that need to be followed are specified in the text of the call.
Thus, this call shall be regarded as a follow-up of an EFSA re-evaluation scientific opinion, and has therefore the same implications as the calls organised by the European Commission, which are published on this site. Consequently, if business operators do not provide the requested data (by the predefined deadline) the present authorisation of this food additive will be revised based on EFSA’s current scientific opinion and the additive may be removed from the Union list of permitted additives. The same applies if the new data submitted are not sufficient for EFSA to conclude the risk assessment, since there will be no successive calls for additional data.
Call for scientific and technical data on the permitted food additive indigotine, indigo carmine (E 132).
Published: 9/3/2018
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 13/4/2018 (CLOSED)
Confirmation of data submission, deadlines and milestones (step 2)
Deadline: 9/9/2018 (CLOSED)
Call for scientific and technical data on the permitted food additive silver (E 174).
Published: 6/3/2018
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 10/4/2018 (CLOSED)
Confirmation of data submission, deadlines and milestones (step 2)
Deadline: 6/9/2018 (CLOSED)
Call for scientific and technical data on the permitted food additive gold (E 175)
Published: 6/3/2018
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 10/4/2018 (CLOSED)
Confirmation of data submission, deadlines and milestones (step 2)
Deadline: 6/9/2018 (CLOSED)
Call for scientific and technical data on the permitted food additives propyl gallate (E 310), octyl gallate (E 311) and dodecyl gallate (E 312).
Published: 30/05/2017
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 07/07/2017 (CLOSED)
Confirmation of data submission, deadlines and milestones (step 2)
Deadline: 30/11/2017 (CLOSED)
Call for scientific and technical data on the permitted food additives E 140(i) chlorophylls, E 140(ii) chlorophyllins, E 141(i) copper complexes of chlorophylls and E 141(ii) copper complexes of chlorophyllins.
Published: 07/04/2017
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 10/05/2017 (CLOSED)
Confirmation of data submission, deadlines and milestones (step 2)
Deadline: 10/10/2017 (CLOSED)
Call for scientific and technical data on the permitted food additive titanium dioxide (E 171).
Published: 30/01/2017
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 02/03/2017 (CLOSED)
Confirmation of data submission, deadlines and milestones (step 2) - updated on 7/5/2019
Deadline: 30/07/2017 (CLOSED)
Call for scientific and technical data on the permitted food additives iron oxides and hydroxides (E 172).
Published: 5/12/2016
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 19/1/2017 (CLOSED)
Confirmation of data submission, deadlines and milestones (step 2)
Deadline: 19/6/2017 (CLOSED)
Call for scientific and technical data on the permitted food additives sulphur dioxide (E 220), sodium sulphite (E 221), sodium bisulphite (E 222), sodium metabisulphite (E 223), potassium metabisulphite (E 224), calcium sulphite (E 226), calcium bisulphite (E 227) and potassium bisulphite (E 228)
Published: 10/10/2016
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 10/11/2016 (CLOSED)
Confirmation of data submission, deadlines and milestones (step 2)
Deadline: 10/4/2017 (CLOSED)
Call for scientific and technical data on the permitted food additives sorbic acid (E 200), potassium sorbate (E 202) and calcium sorbate (E 203).
Published: 10/06/2016
Registration of the contact details of business operators interested in submitting data (step 1)
Deadline: 22/07/2016 (CLOSED)
Confirmation of data submission, deadlines and milestones (step 2)
Deadline: 25/11/2016 (CLOSED)